Sex Hormone Binding Globulin (SHBG)

White Papers

Following an extended period of consulting to AIFS, working closely with the internal team and gaining a deep understanding of their requirements, We were engaged for the design, development and migration of the main AIFS website and numerous sub-sites, onto the Wordpress platform.

WHAT IT IS:

A glycoprotein mostly made by the liver that binds to androgens (DHT, testosterone, androstenediol) and estrogens (estradiol and estrone) to transport them throughout the body.

WHAT IT DOES:

Hormones exist as “bound” or “unbound” (ie free) in the body and are only able to be used by the cells if they are “unbound”. When factors increase the SHBG concentration, the amount of hormone available for use decreases regardless of the actual concentration. So, decreasing the SHBG can actually improve symptomatic relief from the hormones being measured.

FACTORS THAT INCREASE:

Age, estrogen, hyperthyroidism, liver disease, high-fiber diet.

FACTORS THAT DECREASE:

Boron, zinc, aromatase inhibitors, hypothyroidism, growth hormone, high-protein diet. Zinc works to block the receptors that normally bind to androgen and estrogen, thereby preventing the binding capacity of SHBG

RISKS:

Dependent on the factor that modifies the SHBG concentration

BENEFITS:

Increased serum testosterone and estrogen levels